RegNetwork: Regulatory Network Repository of Transcription Factor and microRNA Mediated Gene Regulations

Welcome to RegNetwork! RegNetwork is a data repository of five-type transcriptional and posttranscriptional regulatory relationships for human and mouse:

  1. TF→TF
  2. TF→gene
  3. TF→miRNA
  4. miRNA→TF
  5. miRNA→gene

RegNetwork integrates the curated regulations in various databases and the potential regulations inferred based on the transcription factor binding sites (TFBSs). Transcription factor (TF) and microRNA (miRNA) are central regulators in gene regulations. They function in the transcriptional and posttranscriptional levels respectively. Recently, more and more regulatory relationships in databases and literatures are available. It will greatly valuable for studying gene regulatory systems by integrating the prior knowledge of the transcriptional regulations between TF and target genes, and the posttranscriptional regulations between miRNA and targets. The conservation knowledge of transcription factor binding site (TFBS) can also be implemented to couple the potential regulatory relationships between regulators and their targets.

RegNetwork aims to build a platform for collecting the experimentally validated regulations and the predicted regulations. From RegNetwork, you can query and identify the combinatorial and synergic regulatory relationships among TFs, miRNAs and genes.

Reference:

Zhi-Ping Liu, Canglin Wu, Hongyu Miao and Hulin Wu (2015). RegNetwork: an integrated database of transcriptional and posttranscriptional regulatory networks in human and mouse. Database 2015. doi: 10.1093/database/bav095

Contact Info:

 Canglin Wu